Colombia has extradited Beatriz Henao, who is also known as the Queen of Amphetamines, to the United States where she is wanted on drug trafficking charges.
Henao is accused of being the head of a major international drug-trafficking network shipping large quantities of amphetamines to the US, Spain, and the Netherlands.
Henao was on Interpol's list of its top 10 most wanted women.
US Marshalls also listed her as one of their top three fugitives, along with a US citizen and a Canadian.
The 45-year-old political science graduate had been on the run before her arrest by fourteen agents in a Pereira pizzeria in September 2009.
She was said to be the face of a Colombian drug gang led by Javier Antonio and Luis Enrique Calle Serna, better known as the Comba brothers.
Police have linked her to illegal trafficking of more than 300,000 synthetic drug pills.
Beatriz Henao will face trial in a New York court, alongside two other alleged members of the Comba gang, on charges of drug trafficking and money laundering.